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Electron transport chain of mitochondria carries electrons from universal electron donors such as FADH2 and NADH to O2 via enzyme complexes I, II, III and IV and produces ATP in complex V (Lehninger et al ., 2008)

Li W, Chen W, Peng H, Xiao Z, Liu J, Zeng Y, Huang T, Song Q, Wang X, Xiao Y (2023) Shikonin improves pulmonary vascular remodeling in monocrotalineinduced pulmonary arterial hypertension via regulation of PKM2

IGF-1 is useful precisely because it is slow-moving: unlike GH, whose serum level swings across a single pulse and is hard to capture with a spot measurement, IGF-1 integrates GH exposure over roughly a day, so a sustained rise in IGF-1 is strong evidence that GH output has genuinely increased rather than merely been re-timed

Liquinimod is an immunomodulator which acts to reduce the production of pro-inflammatory cytokines